CBD or Cannabidiol for short is the second-most occurring cannabinoid molecule produced by the hemp plant. Your body has an inbuilt endocannabinoid system, the major molecular system used by the body to control and perform different critical functions. CBD attaches to receptors within this system, actually our bodies were molded to communicate with cannabinoids from the very start and we also produce them naturally. CBD has been known to treat medical conditions like anxiety, depression, glaucoma, epilepsy, chronic pain, insomnia, Parkinson’s, muscle spasms and absence of appetite and body weight. It can also improve sleep, lower inflammation and pain, combat oxidative stress, promote heart health and weight loss, and secure from certain types of cancer. CBD has been found to be particularly effective in treating the neurodegenerative disease, motor neuron disorder.
What Comprises Motor Neuron Disease?
The motor neuron diseases (MNDs) comprise a set of progressive neurological disorders that kill motor neurons, the cells that regulate vital voluntary muscle activity like speaking, breathing, walking, and swallowing. Generally, messages from nerve cells within the brain (termed upper motor neurons) are transferred to nerve cells in the brainstem and spinal cord (known as lower motor neurons) and then onwards to specific muscles. Upper motor neurons guide the lower motor neurons to create motions like walking or chewing. Lower motor neurons regulate motion in the legs, arms, chest, throat, face, and tongue.
In case of disruptions in the signals between the lowest motor neurons and the muscles, the muscles do not function properly and slowly weaken and might start wasting away and incur uncontrollable twitching (known as fasciculation). In the event of disruption in the signals among the upper motor neurons and the lower motor neurons, stiffness (or spasticity) develops in the limb muscles, movements get restricted and effortful, and tendon reflexes like ankle and knee jerks get overactive. With time, the capacity to regulate voluntary movement may be lost.
Causes Of Motor Neuron Disease
No distinctly known cause exists for motor neuron disease.
Commonly, motor neuron disease is believed to happen due to a mix of environmental factors, in the manner of living and as a result of genes.
Nearly 1 in 10 people having motor neuron disease possess a defective gene that resulted in the disorder. Other members of the family may be examined for a mutation in their genes.
Prenatal testing can also be performed.
People have greater propensity to acquire motor neuron disorder if they:
- Were in military service
- Experienced some electrical or mechanical trauma
- Are subject to exposure to heavy metals or agricultural chemicals
- Have been extremely physically active
- Have been smoking or still smoke
Symptoms Of Motor Neuron Disease
Motor neuron disease impacts everyone differently. Everyone doesn’t possess all the symptoms, or in like order, and the pace of progression of symptoms can differ. Obtain assistance from your health and social care experts whenever you notice any alteration.
MND cannot be halted or reversed, but therapies, medication, and equipment can help handle symptoms. These can all aid you attain the finest possible quality of life.
Some or all of the following symptoms may be present:
- Muscle debility, with reduction of muscle mass (wasting), coupled with movement and mobility issues
- Stiff joints, which may restrict the range of movement
- Muscle cramps and spasms, involving rippling sensations (termed fasciculation)
- Speech and communication issues, impacting the way you gesture, speak and display expression
- Pain or discomfort, caused by other symptoms, and not generally by MND directly
- Difficulties in swallowing, impacting how you eat and drink
- Weakened coughing, making it difficult to clear the throat
- Saliva problems, where thin saliva gathers in the mouth or saliva gets thick and sticky
- Problems with breathing, which can cause breathlessness and tiredness
- Alterations in thinking and behavior, for nearly half of those diagnosed with MND
- Emotional lability, with unusual emotional reactions, like laughing when feeling sad
How CBD Helps With Motor Neuron Disease
The inclusion of CBD as an add-on therapy could potentially aid to relieve motor neuron disease symptoms like tight or stiff muscles. It has also been shown to reduce spasticity and pain. Research has indicated the therapeutic advantages of cannabinoids to comprise muscle relaxation, pain-alleviating and anti-inflammatory impacts in patients with different neurological conditions.
How CBD Works To Treat ALS Symptoms?
Amyotrophic Lateral Sclerosis or ALS comprises a neuromuscular disease that impacts the movement of the body’s muscles. This occurs due to degeneration of motor neurons and is a type of motor neuron disorder.
Decreases Production Of Saliva
The effects of CBD in the body allow it to relieve ALS symptoms. It lessens saliva production. In ALS patients are unable to regulate their muscle movement and this also includes the muscles of the mouth. This causes the patients to accumulate excess saliva in the mouth. CBD by reducing saliva production makes the body to utilize the limited saliva created to perform its digestive functions and stop the patient from drooling.
Relaxation Of Muscles
CBD also aids to relax body muscles. This is the converse effect of ALS. Persons suffering from ALS are subject to frequent muscle contractions. This causes symptoms like twitching. The effect of CBD is to do just the opposite and ease some of the tension by relaxing the body.
Research also indicates that CBD aids to control the functioning of the nervous system, like by hastening the speed of breakdown of chemical compounds that are involved in the muscular movement. This helps the patient hugely since at this moment their muscle movement is already compromised and they require an additional boost. Generally, research shows that CBD helps ALS patients extensively to manage the condition.
Helps To Lessen Chronic Pain
CBD has been shown to lower chronic pain. Muscular dysfunction can be extremely discomforting and painful and is all the worse since ALS patients are unable to manage it. CBD aids to ease the pain due to its analgesic properties and proves very useful for patients.
Helps To Induce Sleep
CBD also elevates drowsiness, implying that the patient will have a comparatively easy time sleeping despite all the pain and discomfort.
Stimulates The Appetite
Sickness also causes a general absence of appetite and the case is similar to ALS. CBD can make the user to feel hungry following consumption making it easier for them to eat.
Acts As Bronchodilator
CBD frees up the airways rendering it easier for the patient to breathe.
ALS And The Endocannabinoid System
In ALS therapy, the function of CBD in enzyme functioning is truly important. ALS results from the death of motor neurons in the body. This happens since the waste products created during motor neuron functioning gather in the cells and are not removed by an enzyme called superoxide dismutase. Such waste products, if not eliminated, can seriously harm the motor neuron DNA. CBD assists enzyme function by functioning as an antioxidant and lessening the amount of waste that builds up in the cells due to enzymatic processes.
Act As Antioxidants And Neuroprotectants
Nerve damage in ALS results on account of oxidative stress and excitotoxicity. Cannabinoids display potential in controlling some of the nerve damage, by generally addressing both factors, though more specific studies are needed.
Oxidative stress is caused by an imbalance between free radicals and antioxidants in the body. When the creation of antioxidants cannot match the generation of free radicals, you are unable to detoxify from the harmful effects of free radicals in the body. CBD is a proven antioxidant and assists to reduce the nerve tissue damage caused by free radicals.
Excitotoxicity kills nerve tissue that has already suffered compromise. When nerve tissue is damaged, there is an excessive and uncontrolled release of the amino acid glutamate. This over release causes the death of cells, a destructive process known as excitotoxicity. CBD reduces the discharge of glutamate, thereby saving the neurons from cell death and excitotoxicity.
Conclusion On CBD For Motor Neuron Disease
Summing up, CBD is helpful with regard to easing the symptoms of ALS and other motor neuron disorders. As the disease involves plenty of pain and discomfort, their reduction is extremely important, to increase the life expectancy of the patient, and also make them suffer much less. The properties of CBD help it to ease pain and relax the muscles of the body, which benefits the patient immensely. CBD should be utilized in accordance with directions to obtain the best results. The use of CBD can also be supplemented by other relevant medications and therapies by patients.